EYES-KCS
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http://www.diamondbackdrugs.com/uncategorized/tacrolimus-for-kcs/

Tacrolimus is a calcineuron inhibitor. Its primary use in veterinary medicine is for the treatment of Keratoconjunctivitis Sicca in dogs. Tacrolimus can also be used to treat dermatologic problems such as Superficial Keratitis, Miliary Dermatitis and Atopic Dermatitis.

Tacrolimus may also be a suitable therapy for cats. In some cases, the veterinary drug may be administered to prevent organ rejection following transplant surgery.

Veterinary Medicine — Dogs and KCS

Keratoconjunctivitis Sicca, also known as KCS or dry eye, is an inflammatory condition. The disease is most common in the canine species. It decreases the production of tears, which can eventually lead to blindness. In some cases, KCS may be the outcome of an immune mediated condition.

Veterinary Drugs — Tacrolimus Eye Drops

Tacrolimus is an anti-inflammatory and immunosuppressive drug, often prescribed in veterinary medicine for the ophthalmic treatment of KCS. The ophthalmic drops work to stimulate the tear glands and prevent further destruction of tissue. Some animals with KCS resulting from abnormal activity of the immune system may need to undergo Tacrolimus therapy throughout life.

Veterinary Drugs — Tacrolimus for Dermatologic Conditions

Tacrolimus may also be prescribed in veterinary medicine as a topical cream or ointment for the treatment of a variety of dermatologic conditions.

Tacrolimus Precautions and Side Effects in Veterinary Medicine

Tacrolimus is generally only recommended for topical use. In terms of side effects, both the eye drops and topical ointment have been among the most well received veterinary drugs.

Side effects are rare, but may include slight irritation of the eyes. Extreme reactions may be the result of an allergic response to the drug. Signs of an allergic reaction may include vomiting, seizures, hives and swelling around the face.

Veterinary Drugs — Tacrolimus Dosage and Administration

Your veterinarian will prescribe the dose and provide directions for administering Tacrolimus. In order to achieve the best possible results from treatment with veterinary drugs, it’s important to carefully follow the corresponding instructions.

Dry Eye”
(More formally known as “Keratoconjunctivitis Sicca” or “KCS”)

WHY TEARS ARE GOOD

We can all imagine the discomfort of dry, irritated eyes and the soothing provided by eye drops. Tears are essential to the comfort of our eyes but they do more than just provide lubrication. Tears contain anti-bacterial proteins, salts, sugars, and even oxygen to nourish the eye. Tears flush away irritants and infectious agents that are constantly getting in our eyes. Since the outer portions of the eye does not have a blood supply, the tears must bring sugars and oxygen and must remove metabolic waste.

Tears consist of oil secreted by the eyelid glands, mucus, and (mostly) water. Tears are secreted by two “lacrimal” glands in dogs and cats: one just above the eye and another in the third eyelid (or so-called “nictating membrane”).

Without tears, eyes become irritated, the conjunctival tissues around the eyes get red, the cornea itself in time will turn brown in an effort to protect the eye, and a gooey, yellow discharge predominates. Blindness can result.

Keratoconjunctivitis sicca is a fancy way of saying the eye is dry. “Kerato” refers to the cornea or clear covering of the eye that faces the outside world. “Conjunctivae” are the moist pink membranes of the eye socket. “It is” means inflammation and “sicca” means dry. KCS means inflamed, dry cornea and conjunctiva. It occurs when there is a deficiency in the water portion of the tear film which normally accounts for 95% of the tear volume. Without the water, one is left with oil and mucus; hence, the gooey yellow eye discharge characteristic of this condition.

WHY DO EYES BECOME THIS DRY?

There are many causes of dry eye. Here are some of them:

  • Distemper infection attacks all body interfaces with the environment including the eyes.  Dry eye is part of the constellation of symptoms that can occur with distemper infection. (For more information on Canine Distemper infection click here).
     
  • In cats, Herpes upper respiratory infection can lead to a chronic dry eye. (for more information on feline upper respiratory infections click here).
     
  • There could be a congenital lack of tear producing gland tissue (as described in certain lines of Yorkshire terrier).
     
  • Exposure to sulfa containing antibiotics (such as Trimethoprim sulfa combinations) can lead to dry eye (which can be either temporary or permanent and occurs unpredictably).
     
  • Anesthesia will reduce tear function temporarily (thus eyes are lubricated with ointment by the attending nurse.)
     
  • Removal of the third eyelid tear producing gland (instead of replacing the gland in its proper location) during surgery for Cherry Eye can lead to KCS as can too much damage to the gland prior to proper gland replacement.
     
  • A knock on the head in the area of one of the tear producing glands can lead to KCS.
     
  • The most common cause of KCS appears to be immune mediated destruction of the tear producing gland tissue. We do not know what causes this type of inflammatory reaction but certain breeds are predisposed: the American Cocker Spaniel, the Miniature Schnauzer, and the West Highland White Terrier.

HOW WE MAKE THE KCS DIAGNOSIS

When KCS is in advanced state it is pretty obvious but in earlier cases in may look like a simple case of conjunctivitis. In either case it is important to actually measure the tear production to determine how dry the eyes are. The test that accomplishes this is called the “Schirmer Tear Test.”

To perform the test, a strip of special paper is inserted just inside the lower eyelid in the outer corner of the eye for 60 seconds. The moisture of the eye will wet the paper. At the end of the 60 second period, the height of the moistened area is measured. A height of 15mm or more is normal. A height 11-14mm is a borderline result. A height of less than 10mm is dry. A height less than 5mm is severely dry.

HOW DO WE TREAT THIS CONDITION?

Not that long ago all we had to treat this condition was tear replacement formulas and mucus dissolving agents. These are still helpful but require an impractical frequency of administration. A breakthrough came with the discovery of cyclosporine topical therapy to control the immune mediated gland destruction.

Cyclosporine is an immunomodulating drug that had already been found helpful to organ transplant patients. When applied as an eye drop or ointment, it suppresses the immune destruction that is the most common cause of KCS and tear production is restored.  The success of this treatment plus its convenient dosing interval (once or twice a day) has made this medication the primary treatment for KCS.

In earlier times, animal hospitals made their own cyclosporine eyedrops out of oral cyclosporine and vegetable oil but this largely ended when Schering-Plough came out with Optimmune® eye ointment, containing 0.2% cyclosporine. Currently production problems have made this product difficult to obtain and many practices have resumed making their own eye drops or having compounding pharmacies formulate them.

After beginning cyclosporine eye drops or ointment, a recheck in three weeks or so is a good idea to check for improvement. If the Schirmer tear test is still showing poor results, the medication can be given three times a day; similarly if excellent results are seen, the medication can be dropped to once a day.

Dogs with Schirmer tear tests as low as 2mm still have an 80% chance of responding to cyclosporine.  This medication has been a very miraculous breakthrough in the treatment of KCS. Unfortunately, it is relatively expensive as eye medication goes but after messing around with less effective treatments requiring more frequent administration for less predictable results, cyclosporine is probably worth it.

 

Pilocarpine is what is called a “cholinergic” drug which means it works on the autonomic nervous system (the part that controls automatic functions such as gland secretion).  Without going into too much neurologic detail, this medication can be given in the eye or even orally to stimulate tear production. To use this medication orally, the eye drops are given at an increasing dose until side effects are seen (diarrhea, drooling, vomiting or drop in heart rate). At that point the dose is reduced and continued indefinitely, usually twice a day. Alternatively the drops can be given in the eyes. Recent studies have shown that pilocarpine does not increase tear production in normal dogs so there is some question over how well this method works.

Tacrolimus is another medication able to locally suppress immunity. This product has recently gained popularity in human medication as a topical anti-inflammatory treatment that is cortisone-free.  It does not come in a formulation appropriate for eyes but can be made into one by a compounding pharmacy.  It is used in a manner similar to cyclosporine and is generally of similar cost.

Artificial Tears can be purchased in most drug stores. These can be combined with other therapies and are certainly very soothing. The problem is that they are typically recommended for use 4-6 times a day.
 

 

Antibiotic Products are often needed especially when starting treatment for KCS as secondary infections are common when there are inadequate tears to wash infectious agents away.  These products do not increase tear production but may be important, especially early in therapy.
 

 

Mucomyst® Eye Drops are made from a respiratory product used to dissolve thick mucus. In an eye formula, Mucomyst (active ingredient Acetylcysteine) helps remove the thick eye discharge that accompanies dry eye.

Severin’s Solution is a mixture of Mucomyst, pilocarpine, artificial tears, and antibiotic which can be made up and prescribed. The “recipe” originated in an article published by a veterinary ophthalmologist named Dr. Severin in 1996. Many animal hospitals mix up their own conglomerations based on this recipe. In most cases, cyclosporine has made these mixtures obsolete.

SURGICAL SOLUTIONS?

There is a surgical solution to KCS though it is a delicate procedure in general only done by veterinary ophthalmologists. This is called the Parotid Duct Transposition. The parotid duct is the salivary gland on either side of the facial cheek. It produces saliva which is carried to the mouth via a long duct. This duct can be carefully dissected out and moved so as to deliver saliva over the eye. Saliva actually makes a reasonable substitute for tears though in time some mineral deposits will form on the eye surface and eye drops may be needed to control this. The dog’s eyes will water when he is fed and facial wetting may be objectionable.

The pigment on the surface of the cornea resulting from long standing KCS is like the lens of dark sunglasses and interferes with a dog’s vision especially in dark situations. If tear function is restored, vision may also be restored via a procedure called a Superficial Keratectomy where the pigmented surface of the cornea is sanded away. This is obviously not worth doing if the tear issue is still problematic as the pigment would in that case just return. As with the parotid duct transposition, a veterinary ophthalmologist is probably best suited to perform such a procedure.

The materials, information, and answers provided by and through this website are not intended to replace the services of a trained pet health care professional or to be a substitute for medical advice provided by a qualified veterinarian or other appropriate health care professional. You should consult your own veterinarian or other appropriate health care professional on specific medical questions, including matters requiring diagnosis, treatment, therapy or medical attention.

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